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HLAsupE: An integrated database of HLA supertype-specific epitopes

    Major histocompatibility complex (MHC) molecules bind short peptides derived from endogenous or exogenous antigens and present them onto the surface of antigen-presenting cells (APCs) for T-cell receptor (TCR) recognition. The MHC-binding peptides that can trigger immune response are termed as T-cell epitopes, which are usually vital elements for epitope-based vaccine design. However, human MHC genes (human leucocyte antigens, HLAs) exhibit a high frequency of polymorphisms. So, promiscuous T cell epitopes that can be presented by multiple HLA molecules have great potential in the development of vaccines with wide population coverage. These promiscuous peptides in the context of HLA supertypes are defined as HLA supertype-specific epitopes.

Query tools

Search for HLA supertype specific epitopes
Linear peptide sequence example: "FLPSDFFPSV"
HLA supertype
The first HLA restriction Positive Negative all
The second HLA restriction Positive Negative all
The third HLA restriction Positive Negative all
The fourth HLA restriction Positive Negative all
The fifth HLA restriction Positive Negative all
Select the source species
Map HLA supertype-specific epitopes on a specific protein sequence
Input the protein sequence(plain sequence)
Search for the mutated analogues of a specific epitope
Input the epitope sequence example: "FLPSDFFPSV"
Search for epitopes that including the input sequence substring
Search for mutated analogues of an input peptide mutated analogues (less than 3 mutated position)

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