The same epitope can be recognized in the context of multiple HLA molecules sharing the similar peptides specificities, and which thereby belong to the same supertype, Especially to the class I MHC molecules, So these epitopes were called supertype-specific epitopes. Because of the high HLA polymorphism, identifying promiscuous peptides that bind more than one HLA allele is essential for the development of vaccines with a broad and unbiased coverage of the human population. a collection of the supertyoe-specific epitopes will provide assistance to researchers in the selection of epitopes for corresponding vaccines and selection criteria that suit the needs of their projects