HLA molecules could be clustered into supertypes based on the similarity of peptide binding grooves or peptide binding specificities. Alleles in a supertype share overlapping binding specificity, and peptides that bind to a given HLA class I molecule frequently bind to multiple HLA molecules belonging to the same supertype. These promiscuous binding peptides, called supertype-specific binders, have great potential for the development of vaccines with broad and unbiased coverage of the human population.
    The prediction models generated by a multiplicative average relative binding matrix (mARB) method, the detail about this method can be found here