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HLASSB_DB: HLA class I Supertype-Specific Binders DataBase

    Major histocompatibility complex (MHC) molecules bind short peptides derived from antigens and present these peptides on the surface of antigen-presenting cells (APCs) for recognition by T-cell receptors (TCRs). T-cell epitopes, which are peptides that bind to MHC molecules and trigger an immune response, are important for the development of epitope-based vaccines. MHC genes in humans, which are termed human leucocyte antigens (HLAs), exhibit a high frequency of polymorphisms. HLA molecules could be clustered into supertypes based on the similarity of peptide binding grooves or peptide binding specificities. Peptides that bind to a given HLA class I molecule frequently bind to multiple HLA molecules belonging to the same supertype. These Promiscuous peptides in the context of HLA supertypes were mentioned as HLA supertype-specific binders, showing great potential for the development of vaccines with broad and unbiased coverage of the human population.

 

Query tools
Seach for peptides cross-binding to the HLA molecules in the same supertype
Browse the supertype-specific HLA classI-binding data by source species and protein
Search for HLA supertype-specific binding peptides by protein sequence
Search for mutated analogues of an input peptide
Search for promiscuous peptides binding to alleles across HLA class I supertypes
 

Peptides cross-binding to the HLA molecules in the same supertype
Input a peptide sequence example: "FLPSDFFPSV"
Browse the peptides by supertype
Choose one allele from the selected supertype binders non-binders all
HLA restriction with two alleles binders non-binders all
HLA restriction with three alleles binders non-binders all
HLA restriction with four alleles binders non-binders all
HLA restriction with five alleles binders non-binders all
Select the source species
 

Browse the peptides by source species and protein
Browse the peptides by Source Species
Browse the peptides by Source Protein
 

Search for HLA supertype-specific binding peptides by protein sequence
Input A protein name
Input the protein sequence
 

Search for mutated analogues of an input peptide
Input a peptide sequence example: "FLPSDFFPSV"
Search for peptides that including the input sequence subsequence
Search mutated analogues of input peptide mutated analogues
 

Search for promiscuous peptides binding to alleles across HLA class I supertypes
Supertype 1
Supertype 2
Supertype 3


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